| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2B90 Colorectal cancer |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Transcription-factor regulation |
| Gu-binding protein (PIAS1) |
Colorectal cancer |
Activation |
| Uniprot ID |
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| Interaction Name |
PIAS1-SI interaction |
[1] |
| Studied Cell Lines |
HCT116 cell line |
| Ensembl ID |
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| Description |
Gu-binding protein (PIAS1) is reported to activate the transcription of SI gene, which leads to an increased expression of the drug-metabolizing enzyme Sucrase-isomaltase intestinal. As a result, the interaction between PIAS1 and SI can activate the drug-metabolizing process of Sucrase-isomaltase intestinal. |
| TF factor GATA-4 (GATA4) |
Colorectal cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
GATA4-SI interaction |
[1] |
| Studied Cell Lines |
HCT116 cell line |
| Ensembl ID |
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| Description |
TF factor GATA-4 (GATA4) is reported to activate the transcription of SI gene, which leads to an increased expression of the drug-metabolizing enzyme Sucrase-isomaltase intestinal. As a result, the interaction between GATA4 and SI can activate the drug-metabolizing process of Sucrase-isomaltase intestinal. |
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