Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0459)
DME Name Indoleamine 2,3-dioxygenase 2 (IDO2), Homo sapiens DME Info
UniProt ID
I23O2_HUMAN
EC Number    EC: 1.13.11.52     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.52
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 3A70 Aplastic anemia Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Prothymosin alpha (PTMA) Aplastic anemia Activation
Uniprot ID
PTMA_HUMAN
Interaction Name PTMA-IDO2 interaction [1], [2]
Studied Cell Lines Mesenchymal stem cell line
Description Prothymosin alpha (PTMA) is reported to activate the transcription of IDO2 gene, which leads to an increased expression of the drug-metabolizing enzyme Indoleamine 2,3-dioxygenase 2. As a result, the interaction between PTMA and IDO2 can activate the drug-metabolizing process of Indoleamine 2,3-dioxygenase 2.
References
1 Regulatory effect of thymosin alpha1 on expression of tlr9/ido mRNA in bone marrow mesenchymal stem cells from children with aplastic anemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Dec;18(6):1564-7.
2 An experimental study on the regulation of bone marrow-derived mesenchymal stem cells through indoleamine 2,3-dioxygenase signaling pathway by thymosin alpha1 for improving the immunosuppression mediated by T cell. Zhonghua Er Ke Za Zhi. 2011 Mar;49(3):181-5.

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