Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0460) | |||||
|---|---|---|---|---|---|
| DME Name | Prolyl 4-hydroxylase alpha-2 (P4HA2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.11.2 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-P4HA2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.02E-30; delta-beta: -6.96E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the P4HA2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Prolyl 4-hydroxylase alpha-2. As a result, the interaction between DNMT and P4HA2 can significantly affect the drug-metabolizing process of Prolyl 4-hydroxylase alpha-2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Significant hypomethylation | |||
| Interaction Name | DNMT-P4HA2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.36E-36; delta-beta: -3.45E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the P4HA2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Prolyl 4-hydroxylase alpha-2. As a result, the interaction between DNMT and P4HA2 can significantly affect the drug-metabolizing process of Prolyl 4-hydroxylase alpha-2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-P4HA2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.83E-15; delta-beta: -8.50E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the P4HA2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Prolyl 4-hydroxylase alpha-2. As a result, the interaction between DNMT and P4HA2 can significantly affect the drug-metabolizing process of Prolyl 4-hydroxylase alpha-2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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