| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-21-5p |
Health |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-21-5p--EGLN1 regulation |
[1] |
| Studied Cell Lines |
HK-2 cell line |
| Description |
hsa-miR-21-5p is reported to suppress EGLN1 mRNA translation by binding to the 3' untranslated region (3'UTR) of EGLN1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme HIF-prolyl hydroxylase 2. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| SIR2-like protein 1 (SIRT1) |
Liver cancer |
Repression |
| Uniprot ID |
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| Interaction Name |
SIRT1-EGLN1 interaction |
[2] |
| Studied Cell Lines |
HepG2 cell line |
| Description |
SIR2-like protein 1 (SIRT1) is reported to repress the transcription of EGLN1 gene, which leads to a decreased expression of the drug-metabolizing enzyme HIF-prolyl hydroxylase 2. As a result, the interaction between SIRT1 and EGLN1 can repress the drug-metabolizing process of HIF-prolyl hydroxylase 2. |
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