Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0465)
DME Name UDP-glucose 6-dehydrogenase (UGDH), Homo sapiens DME Info
UniProt ID
UGDH_HUMAN
EC Number    EC: 1.1.1.22     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.22
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Transcription factor Sp1 (SP1) Liver cancer Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-UGDH interaction [1]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of UGDH gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucose 6-dehydrogenase. As a result, the interaction between SP1 and UGDH can activate the drug-metabolizing process of UDP-glucose 6-dehydrogenase.
               ICD-11: 2C77 Cervical cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Transcription factor Sp1 (SP1) Cervical cancer Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-UGDH interaction [1]
Studied Cell Lines HeLa cell line
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of UGDH gene, which leads to an increased expression of the drug-metabolizing enzyme UDP-glucose 6-dehydrogenase. As a result, the interaction between SP1 and UGDH can activate the drug-metabolizing process of UDP-glucose 6-dehydrogenase.
References
1 Analysis of human UDP-glucose dehydrogenase gene promoter: identification of an Sp1 binding site crucial for the expression of the large transcript. J Biochem. 2005 Jun;137(6):703-9.

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