Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0466)
DME Name	Choline kinase alpha (CHKA), Homo sapiens	DME Info
UniProt ID	CHKA_HUMAN
EC Number	EC: 2.7.1.32 (Click to Show/Hide the Complete EC Tree) Transferase Kinase Phosphotransferase EC: 2.7.1.32
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Moderate hypomethylation
Interaction Name	DNMT-CHKA interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 3.05E-02; delta-beta: -2.16E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CHKA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline kinase alpha. As a result, the interaction between DNMT and CHKA can moderatly affect the drug-metabolizing process of Choline kinase alpha.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

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