Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0468) | |||||
|---|---|---|---|---|---|
| DME Name | NADPH:quinone reductase (CRYZ), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.6.5.5 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.58E-133; delta-beta: -2.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CRYZ gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can moderatly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.55E-14; delta-beta: -2.74E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CRYZ gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can moderatly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.90E-07; delta-beta: -2.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CRYZ gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can moderatly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.10E-17; delta-beta: -5.32E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CRYZ gene, which leads to a significantly increased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can significantly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 1.27E-02; delta-beta: 5.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CRYZ gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can significantly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C10 Pancreatic adenocarcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pancreatic adenocarcinoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.25E-02; delta-beta: -5.34E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CRYZ gene, which leads to a significantly increased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can significantly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.74E-03; delta-beta: 2.46E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CRYZ gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can moderatly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Significant hypomethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.32E-15; delta-beta: -4.91E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CRYZ gene, which leads to a significantly increased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can significantly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.15E-05; delta-beta: -5.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CRYZ gene, which leads to a significantly increased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can significantly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 6.74E-09; delta-beta: -3.35E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CRYZ gene, which leads to a significantly increased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can significantly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 15 Musculoskeletal system diseases | |||||
| ICD-11: FA00 Osteoarthritis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Osteoarthritis | Moderate hypermethylation | |||
| Interaction Name | DNMT-CRYZ interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.28E-04; delta-beta: 2.22E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CRYZ gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme NADPH:quinone reductase. As a result, the interaction between DNMT and CRYZ can moderatly affect the drug-metabolizing process of NADPH:quinone reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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