Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0471) | |||||
|---|---|---|---|---|---|
| DME Name | Hydroxyacyl-CoA dehydrogenase 2 (HSD17B10), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.1.35 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-HSD17B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.76E-12; delta-beta: -2.23E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Hydroxyacyl-CoA dehydrogenase 2. As a result, the interaction between DNMT and HSD17B10 can moderatly affect the drug-metabolizing process of Hydroxyacyl-CoA dehydrogenase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglial tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-HSD17B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.40E-03; delta-beta: 2.03E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the HSD17B10 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Hydroxyacyl-CoA dehydrogenase 2. As a result, the interaction between DNMT and HSD17B10 can moderatly affect the drug-metabolizing process of Hydroxyacyl-CoA dehydrogenase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-HSD17B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.69E-13; delta-beta: -2.52E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Hydroxyacyl-CoA dehydrogenase 2. As a result, the interaction between DNMT and HSD17B10 can moderatly affect the drug-metabolizing process of Hydroxyacyl-CoA dehydrogenase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-HSD17B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.35E-04; delta-beta: -3.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HSD17B10 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Hydroxyacyl-CoA dehydrogenase 2. As a result, the interaction between DNMT and HSD17B10 can significantly affect the drug-metabolizing process of Hydroxyacyl-CoA dehydrogenase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-HSD17B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.43E-07; delta-beta: -2.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Hydroxyacyl-CoA dehydrogenase 2. As a result, the interaction between DNMT and HSD17B10 can moderatly affect the drug-metabolizing process of Hydroxyacyl-CoA dehydrogenase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-HSD17B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.39E-71; delta-beta: -2.71E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Hydroxyacyl-CoA dehydrogenase 2. As a result, the interaction between DNMT and HSD17B10 can moderatly affect the drug-metabolizing process of Hydroxyacyl-CoA dehydrogenase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-HSD17B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.36E-11; delta-beta: -2.61E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Hydroxyacyl-CoA dehydrogenase 2. As a result, the interaction between DNMT and HSD17B10 can moderatly affect the drug-metabolizing process of Hydroxyacyl-CoA dehydrogenase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-HSD17B10 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.45E-07; delta-beta: -2.22E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HSD17B10 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Hydroxyacyl-CoA dehydrogenase 2. As a result, the interaction between DNMT and HSD17B10 can moderatly affect the drug-metabolizing process of Hydroxyacyl-CoA dehydrogenase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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