Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0481)
DME Name	Uridine-cytidine kinase 1 (UCK1), Homo sapiens	DME Info
UniProt ID	UCK1_HUMAN
EC Number	EC: 2.7.1.48 (Click to Show/Hide the Complete EC Tree) Transferase Kinase Phosphotransferase EC: 2.7.1.48
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Significant hypomethylation
Interaction Name	DNMT-UCK1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 4.75E-17; delta-beta: -4.82E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the UCK1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Uridine-cytidine kinase 1. As a result, the interaction between DNMT and UCK1 can significantly affect the drug-metabolizing process of Uridine-cytidine kinase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C90 Renal cell carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Renal cell carcinoma		Moderate hypermethylation
Interaction Name	DNMT-UCK1 interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypermethylation p-value: 2.24E-02; delta-beta: 2.38E-02
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the UCK1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Uridine-cytidine kinase 1. As a result, the interaction between DNMT and UCK1 can moderatly affect the drug-metabolizing process of Uridine-cytidine kinase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section

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