Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0482) | |||||
|---|---|---|---|---|---|
| DME Name | Cytosolic 5'-nucleotidase II (NT5C2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.1.3.5 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-NT5C2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.27E-15; delta-beta: -6.54E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NT5C2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytosolic 5'-nucleotidase II. As a result, the interaction between DNMT and NT5C2 can significantly affect the drug-metabolizing process of Cytosolic 5'-nucleotidase II. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-NT5C2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 8.71E-06; delta-beta: -5.06E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NT5C2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cytosolic 5'-nucleotidase II. As a result, the interaction between DNMT and NT5C2 can significantly affect the drug-metabolizing process of Cytosolic 5'-nucleotidase II. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-NT5C2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.04E-10; delta-beta: 3.37E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NT5C2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytosolic 5'-nucleotidase II. As a result, the interaction between DNMT and NT5C2 can significantly affect the drug-metabolizing process of Cytosolic 5'-nucleotidase II. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pleomorphic xanthoastrocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-NT5C2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.10E-02; delta-beta: 2.00E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the NT5C2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytosolic 5'-nucleotidase II. As a result, the interaction between DNMT and NT5C2 can moderatly affect the drug-metabolizing process of Cytosolic 5'-nucleotidase II. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Significant hypermethylation | |||
| Interaction Name | DNMT-NT5C2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.91E-08; delta-beta: 3.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NT5C2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytosolic 5'-nucleotidase II. As a result, the interaction between DNMT and NT5C2 can significantly affect the drug-metabolizing process of Cytosolic 5'-nucleotidase II. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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