Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0484)
DME Name Sphingosine kinase 1 (SPHK1), Homo sapiens DME Info
UniProt ID
SPHK1_HUMAN
EC Number    EC: 2.7.1.91     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.91
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Cerebellar liponeurocytoma Significant hypomethylation
Interaction Name DNMT-SPHK1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 5.38E-10; delta-beta: -6.94E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the SPHK1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Sphingosine kinase 1. As a result, the interaction between DNMT and SPHK1 can significantly affect the drug-metabolizing process of Sphingosine kinase 1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2B90 Colorectal cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-659-3p Colorectal cancer Suppression
miRBase ID
MIMAT0003337
Interaction Name hsa-miR-659-3p--SPHK1 regulation [1]
Studied Cell Lines LOVO and HT29 cell lines
Description hsa-miR-659-3p is reported to suppress SPHK1 mRNA translation by binding to the 3' untranslated region (3'UTR) of SPHK1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Sphingosine kinase 1.
               ICD-11: 2C10 Pancreatic adenocarcinoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-506-3p Pancreatic adenocarcinoma Suppression
miRBase ID
MIMAT0002878
Interaction Name hsa-miR-506-3p--SPHK1 regulation [2]
Studied Cell Lines AsPC-1 and PANC-1 cell lines
Description hsa-miR-506-3p is reported to suppress SPHK1 mRNA translation by binding to the 3' untranslated region (3'UTR) of SPHK1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Sphingosine kinase 1.
               ICD-11: 2C30 Melanoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-124-3p Melanoma Suppression
miRBase ID
MIMAT0000422
Interaction Name hsa-miR-124-3p--SPHK1 regulation [3]
Studied Cell Lines A375 and SKMEL-1 cell lines
Description hsa-miR-124-3p is reported to suppress SPHK1 mRNA translation by binding to the 3' untranslated region (3'UTR) of SPHK1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Sphingosine kinase 1.
               ICD-11: 2C60 Breast cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-125b-5p Breast cancer Suppression
miRBase ID
MIMAT0000423
Interaction Name hsa-miR-125b-5p--SPHK1 regulation [4]
Studied Cell Lines T24 cell line
Description hsa-miR-125b-5p is reported to suppress SPHK1 mRNA translation by binding to the 3' untranslated region (3'UTR) of SPHK1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Sphingosine kinase 1.
               ICD-11: 2C82 Prostate cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Protein BTG2 (BTG2) Prostate cancer Activation
Uniprot ID
BTG2_HUMAN
Interaction Name BTG2-SPHK1 interaction [5]
Studied Cell Lines PC3, LNCaP and DU145 cell lines
Description Protein BTG2 (BTG2) is reported to activate the transcription of SPHK1 gene, which leads to an increased expression of the drug-metabolizing enzyme Sphingosine kinase 1. As a result, the interaction between BTG2 and SPHK1 can activate the drug-metabolizing process of Sphingosine kinase 1.
References
1 miR-659-3p is involved in the regulation of the chemotherapy response of colorectal cancer via modulating the expression of SPHK1. Am J Cancer Res. 2016 Sep 1;6(9):1976-1985.
2 Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-KappaB signaling. Oncogene. 2016 Oct 20;35(42):5501-5514.
3 Reduction of COX-2 through modulating miR-124/SPHK1 axis contributes to the antimetastatic effect of alpinumisoflavone in melanoma. Am J Transl Res. 2017 Mar 15;9(3):986-998.
4 MiRNA-125b inhibits proliferation and migration by targeting SphK1 in bladder cancer. Am J Transl Res. 2015 Nov 15;7(11):2346-54.
5 High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1284-90.

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