| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-433-5p |
Health |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-433-5p--GCLC regulation |
[2] |
| Studied Cell Lines |
Human umbilical vein endothelial cell line |
| Description |
hsa-miR-433-5p is reported to suppress GCLC mRNA translation by binding to the 3' untranslated region (3'UTR) of GCLC mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Glutamate-cysteine ligase catalytic. |
| Histone modification |
| Histone deacetylases (HDACs) |
Health |
Repression |
| Uniprot ID |
|
| Interaction Name |
HDACs-GCLC interaction |
[1] |
| Studied Cell Lines |
Murine TAMH hepatocyte cell line |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the GCLC gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Glutamate-cysteine ligase catalytic. As a result, the interaction between HDACs and GCLC can inhibit the drug-metabolizing process of Glutamate-cysteine ligase catalytic. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2B33 Acute lymphoblastic leukemia |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| Transcription factor Sp1 (SP1) |
Acute lymphoblastic leukemia |
Activation |
| Uniprot ID |
|
| Interaction Name |
SP1-GCLC interaction |
[3], [4] |
| Studied Cell Lines |
HL-60/ADR cell line |
| Ensembl ID |
|
| Description |
Transcription factor Sp1 (SP1) is reported to activate the transcription of GCLC gene, which leads to an increased expression of the drug-metabolizing enzyme Glutamate-cysteine ligase catalytic. As a result, the interaction between SP1 and GCLC can activate the drug-metabolizing process of Glutamate-cysteine ligase catalytic. |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
|
| Transcription-factor regulation |
| NFE2-related factor 2 (NFE2L2) |
Liver cancer |
Repression |
| Uniprot ID |
|
| Interaction Name |
NFE2L2-GCLC interaction |
[5] |
| Studied Cell Lines |
HepG2 cell line |
| Ensembl ID |
|
| Description |
NFE2-related factor 2 (NFE2L2) is reported to repress the transcription of GCLC gene, which leads to a decreased expression of the drug-metabolizing enzyme Glutamate-cysteine ligase catalytic. As a result, the interaction between NFE2L2 and GCLC can repress the drug-metabolizing process of Glutamate-cysteine ligase catalytic. |
| Transcription factor MTF-1 (MTF1) |
Liver cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
MTF1-GCLC interaction |
[6] |
| Studied Cell Lines |
HepG2 cell line |
| Ensembl ID |
|
| Description |
Transcription factor MTF-1 (MTF1) is reported to activate the transcription of GCLC gene, which leads to an increased expression of the drug-metabolizing enzyme Glutamate-cysteine ligase catalytic. As a result, the interaction between MTF1 and GCLC can activate the drug-metabolizing process of Glutamate-cysteine ligase catalytic. |
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