| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-433-5p |
Health |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-433-5p--GCLM regulation |
[2] |
| Studied Cell Lines |
Human umbilical vein endothelial cell line |
| Description |
hsa-miR-433-5p is reported to suppress GCLM mRNA translation by binding to the 3' untranslated region (3'UTR) of GCLM mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Glutamate-cysteine ligase regulatory. |
| Histone modification |
| Histone deacetylases (HDACs) |
Health |
Repression |
| Uniprot ID |
|
| Interaction Name |
HDACs-GCLM interaction |
[1] |
| Studied Cell Lines |
Mouse Model |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the GCLM gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Glutamate-cysteine ligase regulatory. As a result, the interaction between HDACs and GCLM can inhibit the drug-metabolizing process of Glutamate-cysteine ligase regulatory. |
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