Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0487) | |||||
|---|---|---|---|---|---|
| DME Name | Delta-aminolevulinate synthase 2 (ALAS2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.3.1.37 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ALAS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.81E-07; delta-beta: -3.34E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALAS2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Delta-aminolevulinate synthase 2. As a result, the interaction between DNMT and ALAS2 can significantly affect the drug-metabolizing process of Delta-aminolevulinate synthase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-ALAS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.87E-12; delta-beta: -4.41E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ALAS2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Delta-aminolevulinate synthase 2. As a result, the interaction between DNMT and ALAS2 can significantly affect the drug-metabolizing process of Delta-aminolevulinate synthase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B33 Acute lymphoblastic leukemia | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| Transcription-factor regulation | |||||
| ARNT-interacting protein (HIF1A) | Acute lymphoblastic leukemia | Activation | |||
| Uniprot ID | |||||
| Interaction Name | HIF1A-ALAS2 interaction | [1] | |||
| Studied Cell Lines | K562 cell line | ||||
| Ensembl ID | |||||
| Description | ARNT-interacting protein (HIF1A) is reported to activate the transcription of ALAS2 gene, which leads to an increased expression of the drug-metabolizing enzyme Delta-aminolevulinate synthase 2. As a result, the interaction between HIF1A and ALAS2 can activate the drug-metabolizing process of Delta-aminolevulinate synthase 2. | ||||
| Histone modification | |||||
| Histone acetyltransferases (HATs) | Acute lymphoblastic leukemia | Activation | |||
| Uniprot ID | |||||
| Interaction Name | HATs-ALAS2 interaction | [2] | |||
| Studied Cell Lines | K562 cell line | ||||
| Description | Histone acetyltransferases (HATs) are reported to acetylate the ALAS2 gene and thereby activate the transcriptional activity of the drug-metabolizing enzyme Delta-aminolevulinate synthase 2. As a result, the interaction between HATs and ALAS2 can enhance the drug-metabolizing process of Delta-aminolevulinate synthase 2. | ||||
| ICD-11: 2C60 Breast cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Transcription-factor regulation | |||||
| ARNT-interacting protein (HIF1A) | Breast cancer | Activation | |||
| Uniprot ID | |||||
| Interaction Name | HIF1A-ALAS2 interaction | [1] | |||
| Studied Cell Lines | MCF-7 cell line | ||||
| Ensembl ID | |||||
| Description | ARNT-interacting protein (HIF1A) is reported to activate the transcription of ALAS2 gene, which leads to an increased expression of the drug-metabolizing enzyme Delta-aminolevulinate synthase 2. As a result, the interaction between HIF1A and ALAS2 can activate the drug-metabolizing process of Delta-aminolevulinate synthase 2. | ||||
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