| General Information of Drug-Metabolizing Enzyme (DME ID: DME0489) |
| DME Name |
Liver-type arginase (ARG1), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.5.3.1 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Linear amidine hydrolase
EC: 3.5.3.1
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C82 Prostate cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| Androgen receptor (AR) |
Prostate cancer |
Activation |
| Uniprot ID |
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| Interaction Name |
AR-ARG1 interaction |
[1] |
| Studied Cell Lines |
LNCaP, 22Rv1, DU145 and PC3 cell lines |
| Ensembl ID |
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| Description |
Androgen receptor (AR) is reported to activate the transcription of ARG1 gene, which leads to an increased expression of the drug-metabolizing enzyme Liver-type arginase. As a result, the interaction between AR and ARG1 can activate the drug-metabolizing process of Liver-type arginase. |
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| References |
| 1 |
Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer. PLoS One. 2010 Aug 11;5(8):e12107.
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