Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0490) | |||||
|---|---|---|---|---|---|
| DME Name | Chondroitin sulfate glucuronyltransferase (CHPF2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.4.1.226 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-CHPF2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.54E-04; delta-beta: 2.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CHPF2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Chondroitin sulfate glucuronyltransferase. As a result, the interaction between DNMT and CHPF2 can moderatly affect the drug-metabolizing process of Chondroitin sulfate glucuronyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-CHPF2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.74E-04; delta-beta: 2.02E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CHPF2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Chondroitin sulfate glucuronyltransferase. As a result, the interaction between DNMT and CHPF2 can moderatly affect the drug-metabolizing process of Chondroitin sulfate glucuronyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CHPF2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.06E-03; delta-beta: -2.29E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CHPF2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Chondroitin sulfate glucuronyltransferase. As a result, the interaction between DNMT and CHPF2 can moderatly affect the drug-metabolizing process of Chondroitin sulfate glucuronyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-CHPF2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.18E-03; delta-beta: -2.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CHPF2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Chondroitin sulfate glucuronyltransferase. As a result, the interaction between DNMT and CHPF2 can moderatly affect the drug-metabolizing process of Chondroitin sulfate glucuronyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Moderate hypomethylation | |||
| Interaction Name | DNMT-CHPF2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 1.76E-02; delta-beta: -2.44E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CHPF2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Chondroitin sulfate glucuronyltransferase. As a result, the interaction between DNMT and CHPF2 can moderatly affect the drug-metabolizing process of Chondroitin sulfate glucuronyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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