Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0492) | |||||
|---|---|---|---|---|---|
| DME Name | Nicotinate-nucleotide adenylyltransferase 3 (NMNAT3), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.7.7.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 6 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypermethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.70E-11; delta-beta: 4.95E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NMNAT3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can significantly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.67E-22; delta-beta: 7.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NMNAT3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can significantly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglial tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 6.12E-13; delta-beta: 6.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NMNAT3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can significantly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.99E-51; delta-beta: 8.88E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NMNAT3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can significantly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | RELA YAP fusion ependymoma | Significant hypermethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.23E-15; delta-beta: 3.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NMNAT3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can significantly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Significant hypermethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.81E-63; delta-beta: 7.06E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NMNAT3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can significantly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.27E-28; delta-beta: 5.98E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NMNAT3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can significantly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.25E-03; delta-beta: 2.84E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the NMNAT3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can moderatly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypermethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.03E-02; delta-beta: 3.26E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NMNAT3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can significantly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-NMNAT3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.43E-04; delta-beta: -2.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NMNAT3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 3. As a result, the interaction between DNMT and NMNAT3 can moderatly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 3. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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