| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2A11 Brain neuroblastoma |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Neuroblastoma |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-IDE interaction |
[1] |
| Studied Cell Lines |
SH-SY5Y cell line |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the IDE gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Insulin-degrading enzyme. As a result, the interaction between HDACs and IDE can inhibit the drug-metabolizing process of Insulin-degrading enzyme. |
| ICD-11: 2C77 Cervical cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| NFE2-related factor 1 (NFE2L1) |
Cervical cancer |
Activation |
| Uniprot ID |
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| Interaction Name |
NFE2L1-IDE interaction |
[2] |
| Studied Cell Lines |
NIH-3T3 and HeLa cell lines |
| Ensembl ID |
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| Description |
NFE2-related factor 1 (NFE2L1) is reported to activate the transcription of IDE gene, which leads to an increased expression of the drug-metabolizing enzyme Insulin-degrading enzyme. As a result, the interaction between NFE2L1 and IDE can activate the drug-metabolizing process of Insulin-degrading enzyme. |
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