Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0495)
DME Name Tyrosine-protein phosphatase non-receptor 1 (PTP1B), Homo sapiens DME Info
UniProt ID
PTN1_HUMAN
EC Number    EC: 3.1.3.48     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.48
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-210-3p Health Suppression
miRBase ID
MIMAT0000267
Interaction Name hsa-miR-210-3p--PTPN1 regulation [1]
Studied Cell Lines HEK293 cell line
Description hsa-miR-210-3p is reported to suppress PTPN1 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTPN1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Tyrosine-protein phosphatase non-receptor 1.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B90 Colorectal cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-362-3p Colorectal cancer Suppression
miRBase ID
MIMAT0004683
Interaction Name hsa-miR-362-3p--PTPN1 regulation [2]
Studied Cell Lines Colorectal cancer cells
Description hsa-miR-362-3p is reported to suppress PTPN1 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTPN1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Tyrosine-protein phosphatase non-receptor 1.
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-122-5p Liver cancer Suppression
miRBase ID
MIMAT0000421
Interaction Name hsa-miR-122-5p--PTPN1 regulation [3]
Studied Cell Lines HepG2 cell line
Description hsa-miR-122-5p is reported to suppress PTPN1 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTPN1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Tyrosine-protein phosphatase non-receptor 1.
References
1 An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem. 2009 Dec 11;284(50):35134-43.
2 MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer. Int J Cancer. 2013 Jul;133(1):67-78.
3 Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid. Hepatology. 2012 Dec;56(6):2209-20.

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