Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0497)
DME Name Red cell/liver pyruvate kinase (PKLR), Homo sapiens DME Info
UniProt ID
KPYR_HUMAN
EC Number    EC: 2.7.1.40     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.40
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Brain neuroblastoma Significant hypomethylation
Interaction Name DNMT-PKLR interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 3.64E-33; delta-beta: -8.66E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PKLR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Red cell/liver pyruvate kinase. As a result, the interaction between DNMT and PKLR can significantly affect the drug-metabolizing process of Red cell/liver pyruvate kinase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-338-3p Liver cancer Suppression
miRBase ID
MIMAT0000763
Interaction Name hsa-miR-338-3p--PKLR regulation [1]
Studied Cell Lines SMMC-7721 cell line
Description hsa-miR-338-3p is reported to suppress PKLR mRNA translation by binding to the 3' untranslated region (3'UTR) of PKLR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Red cell/liver pyruvate kinase.
References
1 Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR-338-3p-PKLR axis in hepatocellular carcinoma. Hepatology. 2015 Oct;62(4):1145-59.

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