Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0498) | |||||
|---|---|---|---|---|---|
| DME Name | Gamma-glutamyltranspeptidase 1 (GGT1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.4.19.13 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-GGT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.04E-05; delta-beta: -5.73E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GGT1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Gamma-glutamyltranspeptidase 1. As a result, the interaction between DNMT and GGT1 can significantly affect the drug-metabolizing process of Gamma-glutamyltranspeptidase 1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-GGT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.60E-04; delta-beta: -2.17E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GGT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Gamma-glutamyltranspeptidase 1. As a result, the interaction between DNMT and GGT1 can moderatly affect the drug-metabolizing process of Gamma-glutamyltranspeptidase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-GGT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.60E-11; delta-beta: -2.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GGT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Gamma-glutamyltranspeptidase 1. As a result, the interaction between DNMT and GGT1 can moderatly affect the drug-metabolizing process of Gamma-glutamyltranspeptidase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-GGT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.67E-94; delta-beta: -2.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GGT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Gamma-glutamyltranspeptidase 1. As a result, the interaction between DNMT and GGT1 can moderatly affect the drug-metabolizing process of Gamma-glutamyltranspeptidase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypermethylation | |||
| Interaction Name | DNMT-GGT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.58E-34; delta-beta: 5.58E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the GGT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Gamma-glutamyltranspeptidase 1. As a result, the interaction between DNMT and GGT1 can significantly affect the drug-metabolizing process of Gamma-glutamyltranspeptidase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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