Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0503) | |||||
|---|---|---|---|---|---|
| DME Name | Lactate dehydrogenase C (LDHC), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.1.27 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-LDHC interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.96E-58; delta-beta: -2.84E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the LDHC gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lactate dehydrogenase C. As a result, the interaction between DNMT and LDHC can moderatly affect the drug-metabolizing process of Lactate dehydrogenase C. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-LDHC interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.81E-12; delta-beta: -4.95E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the LDHC gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lactate dehydrogenase C. As a result, the interaction between DNMT and LDHC can significantly affect the drug-metabolizing process of Lactate dehydrogenase C. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-LDHC interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.87E-04; delta-beta: -2.64E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the LDHC gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lactate dehydrogenase C. As a result, the interaction between DNMT and LDHC can moderatly affect the drug-metabolizing process of Lactate dehydrogenase C. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-LDHC interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.18E-06; delta-beta: -2.93E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the LDHC gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lactate dehydrogenase C. As a result, the interaction between DNMT and LDHC can moderatly affect the drug-metabolizing process of Lactate dehydrogenase C. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B60 Squamous cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Squamous cell carcinoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-LDHC interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.01E-03; delta-beta: -2.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the LDHC gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lactate dehydrogenase C. As a result, the interaction between DNMT and LDHC can moderatly affect the drug-metabolizing process of Lactate dehydrogenase C. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 2.66E-02; delta-beta: -2.77E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the LDHC gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lactate dehydrogenase C. As a result, the interaction between DNMT and LDHC can moderatly affect the drug-metabolizing process of Lactate dehydrogenase C. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypomethylation | |||
| Interaction Name | DNMT-LDHC interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.81E-03; delta-beta: -3.91E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the LDHC gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lactate dehydrogenase C. As a result, the interaction between DNMT and LDHC can significantly affect the drug-metabolizing process of Lactate dehydrogenase C. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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