Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0504) | |||||
|---|---|---|---|---|---|
| DME Name | NADP-dependent malic enzyme (ME1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.1.40 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Significant hypermethylation | |||
| Interaction Name | DNMT-ME1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.75E-03; delta-beta: 3.77E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ME1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme NADP-dependent malic enzyme. As a result, the interaction between DNMT and ME1 can significantly affect the drug-metabolizing process of NADP-dependent malic enzyme. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Malignant astrocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-ME1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.66E-42; delta-beta: 4.99E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ME1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme NADP-dependent malic enzyme. As a result, the interaction between DNMT and ME1 can significantly affect the drug-metabolizing process of NADP-dependent malic enzyme. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglial tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-ME1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.40E-14; delta-beta: 5.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ME1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme NADP-dependent malic enzyme. As a result, the interaction between DNMT and ME1 can significantly affect the drug-metabolizing process of NADP-dependent malic enzyme. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Significant hypermethylation | |||
| Interaction Name | DNMT-ME1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.18E-21; delta-beta: 5.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ME1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme NADP-dependent malic enzyme. As a result, the interaction between DNMT and ME1 can significantly affect the drug-metabolizing process of NADP-dependent malic enzyme. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-ME1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.38E-05; delta-beta: 3.37E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ME1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme NADP-dependent malic enzyme. As a result, the interaction between DNMT and ME1 can significantly affect the drug-metabolizing process of NADP-dependent malic enzyme. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-ME1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.30E-18; delta-beta: 6.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ME1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme NADP-dependent malic enzyme. As a result, the interaction between DNMT and ME1 can significantly affect the drug-metabolizing process of NADP-dependent malic enzyme. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypermethylation | |||
| Interaction Name | DNMT-ME1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.48E-04; delta-beta: 6.92E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ME1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme NADP-dependent malic enzyme. As a result, the interaction between DNMT and ME1 can significantly affect the drug-metabolizing process of NADP-dependent malic enzyme. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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