General Information of Drug-Metabolizing Enzyme (DME ID: DME0506)
DME Name Factor inhibiting HIF-1 (HIF1AN), Homo sapiens DME Info
UniProt ID
HIF1N_HUMAN
EC Number    EC: 1.14.11.3     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
2-oxoglutarate donor oxidoreductase
EC: 1.14.11.3
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-31-5p Health Suppression
miRBase ID
MIMAT0000089
Interaction Name hsa-miR-31-5p--HIF1AN regulation [1]
Studied Cell Lines Human corneal epithelial keratinocytes
Description hsa-miR-31-5p is reported to suppress HIF1AN mRNA translation by binding to the 3' untranslated region (3'UTR) of HIF1AN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Factor inhibiting HIF-1.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C60 Breast cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-24-1-5p Breast cancer Suppression
miRBase ID
MIMAT0000079
Interaction Name hsa-miR-24-1-5p--HIF1AN regulation [2]
Studied Cell Lines MCF-7 and BT-549 cell lines
Description hsa-miR-24-1-5p is reported to suppress HIF1AN mRNA translation by binding to the 3' untranslated region (3'UTR) of HIF1AN mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Factor inhibiting HIF-1.
References
1 MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism. FASEB J. 2012 Aug;26(8):3140-7.
2 MiR-24 induces chemotherapy resistance and hypoxic advantage in breast cancer. Oncotarget. 2017 Mar 21;8(12):19507-19521.

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