Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0512) | |||||
|---|---|---|---|---|---|
| DME Name | Dinucleosidetriphosphatase (FHIT), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.6.1.29 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification Healthy | |||||
| ICD-11: Healthy | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Transcription-factor regulation | |||||
| TF factor E2F1 (E2F1) | Health | Repression | |||
| Uniprot ID | |||||
| Interaction Name | E2F1-FHIT interaction | [1] | |||
| Studied Cell Lines | Fibroblasts | ||||
| Ensembl ID | |||||
| Description | TF factor E2F1 (E2F1) is reported to repress the transcription of FHIT gene, which leads to a decreased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. As a result, the interaction between E2F1 and FHIT can repress the drug-metabolizing process of Dinucleosidetriphosphatase. | ||||
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-FHIT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.74E-10; delta-beta: -3.76E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FHIT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. As a result, the interaction between DNMT and FHIT can significantly affect the drug-metabolizing process of Dinucleosidetriphosphatase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-FHIT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.69E-06; delta-beta: -2.58E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FHIT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. As a result, the interaction between DNMT and FHIT can moderatly affect the drug-metabolizing process of Dinucleosidetriphosphatase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-FHIT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.50E-12; delta-beta: 4.10E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FHIT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. As a result, the interaction between DNMT and FHIT can significantly affect the drug-metabolizing process of Dinucleosidetriphosphatase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pleomorphic xanthoastrocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-FHIT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.04E-07; delta-beta: 3.72E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FHIT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. As a result, the interaction between DNMT and FHIT can significantly affect the drug-metabolizing process of Dinucleosidetriphosphatase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| Non-coding RNA regulation | |||||
| hsa-miR-143-3p | Lung cancer | Suppression | |||
| miRBase ID | |||||
| Interaction Name | hsa-miR-143-3p--FHIT regulation | [2] | |||
| Studied Cell Lines | A549 cell line | ||||
| Description | hsa-miR-143-3p is reported to suppress FHIT mRNA translation by binding to the 3' untranslated region (3'UTR) of FHIT mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. | ||||
| hsa-miR-217 | Lung cancer | Suppression | |||
| miRBase ID | |||||
| Interaction Name | hsa-miR-217--FHIT regulation | [2] | |||
| Studied Cell Lines | A549 cell line | ||||
| Description | hsa-miR-217 is reported to suppress FHIT mRNA translation by binding to the 3' untranslated region (3'UTR) of FHIT mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. | ||||
| hsa-miR-331-3p | Lung cancer | Suppression | |||
| miRBase ID | |||||
| Interaction Name | hsa-miR-331-3p--FHIT regulation | [2] | |||
| Studied Cell Lines | A549 cell line | ||||
| Description | hsa-miR-331-3p is reported to suppress FHIT mRNA translation by binding to the 3' untranslated region (3'UTR) of FHIT mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. | ||||
| hsa-miR-625-5p | Lung cancer | Suppression | |||
| miRBase ID | |||||
| Interaction Name | hsa-miR-625-5p--FHIT regulation | [2] | |||
| Studied Cell Lines | A549 cell line | ||||
| Description | hsa-miR-625-5p is reported to suppress FHIT mRNA translation by binding to the 3' untranslated region (3'UTR) of FHIT mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. | ||||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-FHIT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.38E-03; delta-beta: 8.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FHIT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. As a result, the interaction between DNMT and FHIT can significantly affect the drug-metabolizing process of Dinucleosidetriphosphatase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FHIT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.15E-16; delta-beta: -4.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FHIT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. As a result, the interaction between DNMT and FHIT can significantly affect the drug-metabolizing process of Dinucleosidetriphosphatase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-FHIT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 7.35E-04; delta-beta: 2.06E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the FHIT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Dinucleosidetriphosphatase. As a result, the interaction between DNMT and FHIT can moderatly affect the drug-metabolizing process of Dinucleosidetriphosphatase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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