General Information of Drug-Metabolizing Enzyme (DME ID: DME0514)
DME Name UDP-glucose pyrophosphorylase (UGPase), Homo sapiens DME Info
UniProt ID
UGPA_HUMAN
EC Number    EC: 2.7.7.9     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Nucleotidyltransferase
EC: 2.7.7.9
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
               ICD-11: 5A61 Pituitary gland hypofunction Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Chordoma Moderate hypomethylation
Interaction Name DNMT-UGPase interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 9.66E-03; delta-beta: -2.48E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the UGPase gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme UDP-glucose pyrophosphorylase. As a result, the interaction between DNMT and UGPase can moderatly affect the drug-metabolizing process of UDP-glucose pyrophosphorylase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
               ICD-11: 5B81 Obesity Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Obesity Significant hypomethylation
Interaction Name DNMT-UGPase interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.57E-16; delta-beta: -7.39E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the UGPase gene, which leads to a significantly increased expression of the drug-metabolizing enzyme UDP-glucose pyrophosphorylase. As a result, the interaction between DNMT and UGPase can significantly affect the drug-metabolizing process of UDP-glucose pyrophosphorylase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.