Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0522) | |||||
|---|---|---|---|---|---|
| DME Name | Glucosamine-6-phosphate deaminase 2 (GNPDA2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.5.99.6 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2C90 Renal cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Renal cell carcinoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-GNPDA2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypermethylation p-value: 4.38E-04; delta-beta: 2.15E-02 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GNPDA2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Glucosamine-6-phosphate deaminase 2. As a result, the interaction between DNMT and GNPDA2 can moderatly affect the drug-metabolizing process of Glucosamine-6-phosphate deaminase 2. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
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