Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0525)
DME Name Inositol polyphosphate 4-phosphatase I (INPP4A), Homo sapiens DME Info
UniProt ID
INP4A_HUMAN
EC Number    EC: 3.1.3.66     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.66
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B30 Lymphoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Lymphoma Significant hypomethylation
Interaction Name DNMT-INPP4A interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 3.74E-10; delta-beta: -4.02E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the INPP4A gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Inositol polyphosphate 4-phosphatase I. As a result, the interaction between DNMT and INPP4A can significantly affect the drug-metabolizing process of Inositol polyphosphate 4-phosphatase I.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-3127-5p Liver cancer Suppression
miRBase ID
MIMAT0014990
Interaction Name hsa-miR-3127-5p--INPP4A regulation [1]
Studied Cell Lines Hepatocellular carcinoma cells
Description hsa-miR-3127-5p is reported to suppress INPP4A mRNA translation by binding to the 3' untranslated region (3'UTR) of INPP4A mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Inositol polyphosphate 4-phosphatase I.
References
1 MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation. Oncotarget. 2015 Mar 20;6(8):6359-72.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.