Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0530) | |||||
|---|---|---|---|---|---|
| DME Name | Choline glycerophosphodiester phosphodiesterase (ENPP6), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.1.4.3 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 12 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.08E-14; delta-beta: 2.00E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ENPP6 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.31E-12; delta-beta: 2.98E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ENPP6 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Central neurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.01E-08; delta-beta: -4.05E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ENPP6 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can significantly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 8.83E-13; delta-beta: 4.57E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ENPP6 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can significantly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.60E-06; delta-beta: 2.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ENPP6 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Significant hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.71E-09; delta-beta: 3.24E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ENPP6 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can significantly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.16E-07; delta-beta: -3.00E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ENPP6 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.65E-24; delta-beta: -2.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ENPP6 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 6.29E-05; delta-beta: 2.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ENPP6 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Significant hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.67E-12; delta-beta: 4.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ENPP6 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can significantly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.52E-05; delta-beta: 2.17E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ENPP6 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.36E-03; delta-beta: 2.82E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ENPP6 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 9.67E-37; delta-beta: -2.96E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ENPP6 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.88E-13; delta-beta: -2.25E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ENPP6 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.83E-38; delta-beta: -2.86E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ENPP6 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Significant hypermethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.14E-12; delta-beta: 3.78E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ENPP6 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can significantly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-ENPP6 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.53E-23; delta-beta: -2.84E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ENPP6 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline glycerophosphodiester phosphodiesterase. As a result, the interaction between DNMT and ENPP6 can moderatly affect the drug-metabolizing process of Choline glycerophosphodiester phosphodiesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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