Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0531) | |||||
|---|---|---|---|---|---|
| DME Name | Alanine aminotransferase 1 (GPT), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.6.1.2 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 8 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.83E-07; delta-beta: -3.22E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can significantly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.70E-12; delta-beta: -4.10E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can significantly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Central neurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.45E-08; delta-beta: -5.81E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can significantly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Vestibular melanotic schwannoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.02E-04; delta-beta: -2.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GPT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.01E-02; delta-beta: 3.00E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GPT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.40E-05; delta-beta: -3.81E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can significantly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.69E-37; delta-beta: -2.98E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GPT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Significant hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.64E-03; delta-beta: -3.94E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can significantly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 5.43E-40; delta-beta: 2.81E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GPT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.64E-07; delta-beta: -2.25E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GPT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypomethylation p-value: 5.10E-06; delta-beta: -2.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GPT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C73 Ovarian cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Ovarian cancer | Significant hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.32E-03; delta-beta: -3.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can significantly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.32E-05; delta-beta: -2.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GPT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.30E-63; delta-beta: -3.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can significantly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 8.08E-07; delta-beta: 2.18E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GPT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.80E-03; delta-beta: -2.51E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GPT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-GPT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.57E-12; delta-beta: -2.58E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GPT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alanine aminotransferase 1. As a result, the interaction between DNMT and GPT can moderatly affect the drug-metabolizing process of Alanine aminotransferase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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