Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0532) | |||||
|---|---|---|---|---|---|
| DME Name | Phosphoserine aminotransferase (PSAT1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.6.1.52 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 8 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Significant hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 6.03E-56; delta-beta: 4.84E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PSAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can significantly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Central neurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.78E-06; delta-beta: -3.00E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PSAT1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can significantly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebral hemispheric glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.27E-04; delta-beta: -2.66E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can moderatly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.18E-17; delta-beta: 5.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PSAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can significantly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.47E-15; delta-beta: -2.83E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can moderatly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.13E-05; delta-beta: -2.60E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can moderatly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.39E-13; delta-beta: -2.57E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can moderatly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.44E-16; delta-beta: 4.89E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PSAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can significantly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Significant hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.21E-41; delta-beta: 3.72E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PSAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can significantly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 6.02E-05; delta-beta: 2.83E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PSAT1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can moderatly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.79E-46; delta-beta: -2.95E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PSAT1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can moderatly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 9.81E-05; delta-beta: 2.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PSAT1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can moderatly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Significant hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.42E-11; delta-beta: 4.76E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PSAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can significantly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Significant hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.05E-05; delta-beta: 4.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PSAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can significantly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.55E-06; delta-beta: 2.68E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PSAT1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can moderatly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 12 Respiratory system diseases | |||||
| ICD-11: CB05 Granulomatous lung disease | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Granulomatous lung disease | Moderate hypermethylation | |||
| Interaction Name | DNMT-PSAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.39E-05; delta-beta: 2.29E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PSAT1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Phosphoserine aminotransferase. As a result, the interaction between DNMT and PSAT1 can moderatly affect the drug-metabolizing process of Phosphoserine aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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