Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0535) | |||||
|---|---|---|---|---|---|
| DME Name | Thyroxine 5-deiodinase (DIO3), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.21.99.3 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 7 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-DIO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.46E-57; delta-beta: -2.49E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DIO3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Thyroxine 5-deiodinase. As a result, the interaction between DNMT and DIO3 can moderatly affect the drug-metabolizing process of Thyroxine 5-deiodinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-DIO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.01E-08; delta-beta: 3.89E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the DIO3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Thyroxine 5-deiodinase. As a result, the interaction between DNMT and DIO3 can significantly affect the drug-metabolizing process of Thyroxine 5-deiodinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-DIO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 9.02E-18; delta-beta: 4.53E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the DIO3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Thyroxine 5-deiodinase. As a result, the interaction between DNMT and DIO3 can significantly affect the drug-metabolizing process of Thyroxine 5-deiodinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | RELA YAP fusion ependymoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-DIO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 7.93E-18; delta-beta: 2.25E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the DIO3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Thyroxine 5-deiodinase. As a result, the interaction between DNMT and DIO3 can moderatly affect the drug-metabolizing process of Thyroxine 5-deiodinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-DIO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 4.09E-04; delta-beta: 2.85E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the DIO3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Thyroxine 5-deiodinase. As a result, the interaction between DNMT and DIO3 can moderatly affect the drug-metabolizing process of Thyroxine 5-deiodinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-DIO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.46E-09; delta-beta: 2.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the DIO3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Thyroxine 5-deiodinase. As a result, the interaction between DNMT and DIO3 can moderatly affect the drug-metabolizing process of Thyroxine 5-deiodinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-DIO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.66E-03; delta-beta: 2.18E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the DIO3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Thyroxine 5-deiodinase. As a result, the interaction between DNMT and DIO3 can moderatly affect the drug-metabolizing process of Thyroxine 5-deiodinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-DIO3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.49E-04; delta-beta: 2.72E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the DIO3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Thyroxine 5-deiodinase. As a result, the interaction between DNMT and DIO3 can moderatly affect the drug-metabolizing process of Thyroxine 5-deiodinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.