Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0538)
DME Name	Cyclic ADP-ribose hydrolase 1 (CD38), Homo sapiens	DME Info
UniProt ID	CD38_HUMAN
EC Number	EC: 3.2.2.6 (Click to Show/Hide the Complete EC Tree) Hydrolases Glycosylase N-Glycosyl compound glycosidase EC: 3.2.2.6
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Proto-oncogene c-Myc (MYC)		Health		Activation
Uniprot ID	MYC_HUMAN
Interaction Name	MYC-CD38 interaction				[2]
Studied Cell Lines	EREB2-5 cell line
Ensembl ID	ENSG00000136997
Description	Proto-oncogene c-Myc (MYC) is reported to activate the transcription of CD38 gene, which leads to an increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between MYC and CD38 can activate the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
Non-coding RNA regulation
hsa-miR-140-3p		Health		Suppression
miRBase ID	MIMAT0004597
Interaction Name	hsa-miR-140-3p--CD38 regulation				[1]
Studied Cell Lines	Airway smooth muscle cells
Description	hsa-miR-140-3p is reported to suppress CD38 mRNA translation by binding to the 3' untranslated region (3'UTR) of CD38 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 9 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Glioblastoma		Moderate hypomethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.72E-06; delta-beta: -2.14E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CD38 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can moderatly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Central neurocytoma		Moderate hypomethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.46E-06; delta-beta: -2.95E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CD38 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can moderatly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Cerebral hemispheric glioma		Moderate hypomethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 8.50E-06; delta-beta: -2.45E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CD38 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can moderatly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Melanocytoma		Significant hypermethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 3.71E-10; delta-beta: 3.11E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CD38 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can significantly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Myxopapillary ependymoma		Significant hypomethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 4.53E-13; delta-beta: -3.22E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CD38 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can significantly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Cerebellar liponeurocytoma		Significant hypomethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.60E-06; delta-beta: -4.04E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CD38 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can significantly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Third ventricle chordoid glioma		Moderate hypomethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 3.76E-04; delta-beta: -2.68E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CD38 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can moderatly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Spinal ependymoma		Significant hypomethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 6.25E-18; delta-beta: -3.83E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CD38 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can significantly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Oligodendroglioma		Significant hypermethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 2.70E-23; delta-beta: 3.14E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CD38 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can significantly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2A83 Multiple myeloma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylases (HDACs)		Multiple myeloma		Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-CD38 interaction				[3]
Studied Cell Lines	Multiple myeloma cell line
Description	Histone deacetylases (HDACs) are reported to deacetylate the CD38 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between HDACs and CD38 can inhibit the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Significant hypomethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.83E-26; delta-beta: -3.59E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CD38 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can significantly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B71 Gastric cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Gastric cancer		Moderate hypermethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypermethylation p-value: 3.11E-02; delta-beta: 2.21E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CD38 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can moderatly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2C30 Melanoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanoma		Moderate hypermethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.68E-04; delta-beta: 2.50E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CD38 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can moderatly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Posterior fossa ependymoma		Moderate hypomethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.78E-35; delta-beta: -2.65E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CD38 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can moderatly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Significant hypermethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 3.55E-05; delta-beta: 3.98E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CD38 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can significantly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5B81 Obesity		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Obesity		Significant hypermethylation
Interaction Name	DNMT-CD38 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 5.85E-14; delta-beta: 3.88E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CD38 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cyclic ADP-ribose hydrolase 1. As a result, the interaction between DNMT and CD38 can significantly affect the drug-metabolizing process of Cyclic ADP-ribose hydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	miR-140-3p regulation of TNF-alpha-induced CD38 expression in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(5):L460-8.
2	Antagonistic effects of c-myc and Epstein-Barr virus latent genes on the phenotype of human B cells. Int J Cancer. 2001 Sep;93(6):810-6.
3	Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab. Leukemia. 2020 Apr 29.

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