Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0539)
DME Name Nicotinate-nucleotide adenylyltransferase 2 (NMNAT2), Homo sapiens DME Info
UniProt ID
NMNA2_HUMAN
EC Number    EC: 2.7.7.1     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Nucleotidyltransferase
EC: 2.7.7.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B30 Lymphoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Lymphoma Moderate hypomethylation
Interaction Name DNMT-NMNAT2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 1.75E-09; delta-beta: -2.68E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NMNAT2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 2. As a result, the interaction between DNMT and NMNAT2 can moderatly affect the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 2.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2C30 Melanoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Melanoma Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-NMNAT2 interaction [1]
Studied Cell Lines SK-MEL-3 cell line
Description Histone deacetylases (HDACs) are reported to deacetylate the NMNAT2 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Nicotinate-nucleotide adenylyltransferase 2. As a result, the interaction between HDACs and NMNAT2 can inhibit the drug-metabolizing process of Nicotinate-nucleotide adenylyltransferase 2.
References
1 Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. Cancer Genomics Proteomics. Sep-Oct 2018;15(5):349-364.

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