Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0542) | |||||
|---|---|---|---|---|---|
| DME Name | Oxaloacetate decarboxylase (FAHD1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.7.1.5 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 12 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Anaplastic pilocytic astrocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.44E-11; delta-beta: -2.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FAHD1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can moderatly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Medulloblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.66E-78; delta-beta: -5.78E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 8.11E-33; delta-beta: -6.83E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Mixed neuronal-glial tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.63E-09; delta-beta: -2.11E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FAHD1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can moderatly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.11E-24; delta-beta: -4.33E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebral hemispheric glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.29E-02; delta-beta: -2.34E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FAHD1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can moderatly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.59E-09; delta-beta: -3.75E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | RELA YAP fusion ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.66E-35; delta-beta: -3.82E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.27E-05; delta-beta: -6.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.55E-56; delta-beta: -5.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.28E-21; delta-beta: -3.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.91E-13; delta-beta: -4.17E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.88E-81; delta-beta: -4.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.53E-09; delta-beta: -2.33E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FAHD1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can moderatly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 3.31E-05; delta-beta: -2.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FAHD1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can moderatly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypomethylation p-value: 1.84E-04; delta-beta: -2.11E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FAHD1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can moderatly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.32E-10; delta-beta: -3.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 8.15E-97; delta-beta: -4.44E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F7C Connective tissue cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Hemangioblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.31E-12; delta-beta: -4.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.76E-23; delta-beta: -5.45E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.50E-03; delta-beta: -3.91E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-FAHD1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.29E-11; delta-beta: -3.51E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FAHD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Oxaloacetate decarboxylase. As a result, the interaction between DNMT and FAHD1 can significantly affect the drug-metabolizing process of Oxaloacetate decarboxylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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