Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0543) | |||||
|---|---|---|---|---|---|
| DME Name | Phenylethanolamine N-methyltransferase (PNMT), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.1.1.28 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Malignant astrocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-PNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.09E-57; delta-beta: 2.64E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PNMT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Phenylethanolamine N-methyltransferase. As a result, the interaction between DNMT and PNMT can moderatly affect the drug-metabolizing process of Phenylethanolamine N-methyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglial tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-PNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.13E-07; delta-beta: 4.71E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PNMT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phenylethanolamine N-methyltransferase. As a result, the interaction between DNMT and PNMT can significantly affect the drug-metabolizing process of Phenylethanolamine N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Significant hypermethylation | |||
| Interaction Name | DNMT-PNMT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.58E-45; delta-beta: 5.21E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PNMT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Phenylethanolamine N-methyltransferase. As a result, the interaction between DNMT and PNMT can significantly affect the drug-metabolizing process of Phenylethanolamine N-methyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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