Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0544)
DME Name	Maillard deglycase (PARK7), Homo sapiens	DME Info
UniProt ID	PARK7_HUMAN
EC Number	EC: 3.5.1.124 (Click to Show/Hide the Complete EC Tree) Hydrolases Carbon-nitrogen hydrolase Linear amide hydrolase EC: 3.5.1.124
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-PARK7 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 5.70E-05; delta-beta: -3.20E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PARK7 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Maillard deglycase. As a result, the interaction between DNMT and PARK7 can significantly affect the drug-metabolizing process of Maillard deglycase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2D10 Thyroid cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Thyroid cancer		Moderate hypermethylation
Interaction Name	DNMT-PARK7 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 8.10E-06; delta-beta: 2.42E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PARK7 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Maillard deglycase. As a result, the interaction between DNMT and PARK7 can moderatly affect the drug-metabolizing process of Maillard deglycase.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypermethylation p-value: 3.17E-09; delta-beta: 2.83E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PARK7 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Maillard deglycase. As a result, the interaction between DNMT and PARK7 can moderatly affect the drug-metabolizing process of Maillard deglycase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 11 Circulatory system diseases
ICD-11: BD51 Arterial aneurysm		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Arterial aneurysm		Significant hypermethylation
Interaction Name	DNMT-PARK7 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 3.13E-03; delta-beta: 3.59E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PARK7 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Maillard deglycase. As a result, the interaction between DNMT and PARK7 can significantly affect the drug-metabolizing process of Maillard deglycase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual

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