Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0548)
DME Name	Dimethylarginine dimethylaminohydrolase 1 (DDAH1), Homo sapiens	DME Info
UniProt ID	DDAH1_HUMAN
EC Number	EC: 3.5.3.18 (Click to Show/Hide the Complete EC Tree) Hydrolases Carbon-nitrogen hydrolase Linear amidine hydrolase EC: 3.5.3.18
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Non-coding RNA regulation
hsa-miR-210-3p		Health		Suppression
miRBase ID	MIMAT0000267
Interaction Name	hsa-miR-210-3p--DDAH1 regulation				[1]
Studied Cell Lines	HEK293 cell line
Description	hsa-miR-210-3p is reported to suppress DDAH1 mRNA translation by binding to the 3' untranslated region (3'UTR) of DDAH1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dimethylarginine dimethylaminohydrolase 1.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-DDAH1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.19E-21; delta-beta: -6.14E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DDAH1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Dimethylarginine dimethylaminohydrolase 1. As a result, the interaction between DNMT and DDAH1 can significantly affect the drug-metabolizing process of Dimethylarginine dimethylaminohydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Vestibular melanotic schwannoma		Moderate hypomethylation
Interaction Name	DNMT-DDAH1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 5.66E-05; delta-beta: -2.18E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DDAH1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Dimethylarginine dimethylaminohydrolase 1. As a result, the interaction between DNMT and DDAH1 can moderatly affect the drug-metabolizing process of Dimethylarginine dimethylaminohydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Non-coding RNA regulation
hsa-miR-21-5p		Lung cancer		Suppression
miRBase ID	MIMAT0000076
Interaction Name	hsa-miR-21-5p--DDAH1 regulation				[2]
Studied Cell Lines	A549 cell line
Description	hsa-miR-21-5p is reported to suppress DDAH1 mRNA translation by binding to the 3' untranslated region (3'UTR) of DDAH1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Dimethylarginine dimethylaminohydrolase 1.
ICD Disease Classification 11 Circulatory system diseases
ICD-11: BD51 Arterial aneurysm		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Arterial aneurysm		Significant hypermethylation
Interaction Name	DNMT-DDAH1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 3.44E-02; delta-beta: 4.12E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the DDAH1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Dimethylarginine dimethylaminohydrolase 1. As a result, the interaction between DNMT and DDAH1 can significantly affect the drug-metabolizing process of Dimethylarginine dimethylaminohydrolase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual

References
1	An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem. 2009 Dec 11;284(50):35134-43.
2	Lipid Nanoparticles Composed of Quaternary Amine-Tertiary Amine Cationic Lipid Combination (QTsome) for Therapeutic Delivery of AntimiR-21 for Lung Cancer. Mol Pharm. 2016 Feb 1;13(2):653-62.

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