| General Information of Drug-Metabolizing Enzyme (DME ID: DME0563) |
| DME Name |
Carboxypeptidase M (CPM), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.4.17.12 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Metallocarboxypeptidase
EC: 3.4.17.12
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2B90 Colorectal cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-146a-5p |
Colorectal cancer |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-146a-5p--CPM regulation |
[1] |
| Studied Cell Lines |
HT-29 cell line |
| Description |
hsa-miR-146a-5p is reported to suppress CPM mRNA translation by binding to the 3' untranslated region (3'UTR) of CPM mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Carboxypeptidase M. |
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| References |
| 1 |
MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway. Oncotarget. 2017 Apr 4;8(14):22674-22684.
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