Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0565) | |||||
|---|---|---|---|---|---|
| DME Name | D-amino-acid oxidase (DAO), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.4.3.3 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-DAO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.96E-05; delta-beta: -3.57E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DAO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme D-amino-acid oxidase. As a result, the interaction between DNMT and DAO can significantly affect the drug-metabolizing process of D-amino-acid oxidase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-DAO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.80E-03; delta-beta: -2.50E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DAO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme D-amino-acid oxidase. As a result, the interaction between DNMT and DAO can moderatly affect the drug-metabolizing process of D-amino-acid oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-DAO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.74E-11; delta-beta: -2.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DAO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme D-amino-acid oxidase. As a result, the interaction between DNMT and DAO can moderatly affect the drug-metabolizing process of D-amino-acid oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Significant hypermethylation | |||
| Interaction Name | DNMT-DAO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.16E-04; delta-beta: 7.21E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the DAO gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme D-amino-acid oxidase. As a result, the interaction between DNMT and DAO can significantly affect the drug-metabolizing process of D-amino-acid oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-DAO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.89E-13; delta-beta: -2.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DAO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme D-amino-acid oxidase. As a result, the interaction between DNMT and DAO can moderatly affect the drug-metabolizing process of D-amino-acid oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-DAO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.34E-05; delta-beta: 4.03E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the DAO gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme D-amino-acid oxidase. As a result, the interaction between DNMT and DAO can significantly affect the drug-metabolizing process of D-amino-acid oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-DAO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.59E-77; delta-beta: -5.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DAO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme D-amino-acid oxidase. As a result, the interaction between DNMT and DAO can significantly affect the drug-metabolizing process of D-amino-acid oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F7C Connective tissue cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Hemangioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-DAO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.65E-03; delta-beta: -2.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DAO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme D-amino-acid oxidase. As a result, the interaction between DNMT and DAO can moderatly affect the drug-metabolizing process of D-amino-acid oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-DAO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.41E-18; delta-beta: -3.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the DAO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme D-amino-acid oxidase. As a result, the interaction between DNMT and DAO can significantly affect the drug-metabolizing process of D-amino-acid oxidase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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