Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0566)
DME Name	Prostaglandin dehydrogenase 1 (HPGD), Homo sapiens	DME Info
UniProt ID	PGDH_HUMAN
EC Number	EC: 1.1.1.141 (Click to Show/Hide the Complete EC Tree) Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.141
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanocytoma		Moderate hypomethylation
Interaction Name	DNMT-HPGD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 4.87E-03; delta-beta: -2.82E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the HPGD gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Prostaglandin dehydrogenase 1. As a result, the interaction between DNMT and HPGD can moderatly affect the drug-metabolizing process of Prostaglandin dehydrogenase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B62 Tongue squamous cell carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Non-coding RNA regulation
hsa-miR-21-3p		Tongue squamous cell carcinoma		Suppression
miRBase ID	MIMAT0004494
Interaction Name	hsa-miR-21-3p--HPGD regulation				[1]
Studied Cell Lines	UM1, UM2, SCC9 and Tca8113 cell lines
Description	hsa-miR-21-3p is reported to suppress HPGD mRNA translation by binding to the 3' untranslated region (3'UTR) of HPGD mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin dehydrogenase 1.
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Non-coding RNA regulation
hsa-miR-21-5p		Liver cancer		Suppression
miRBase ID	MIMAT0000076
Interaction Name	hsa-miR-21-5p--HPGD regulation				[2]
Studied Cell Lines	CCLP1, SG231, HuCCT1 and TFK1 cell lines
Description	hsa-miR-21-5p is reported to suppress HPGD mRNA translation by binding to the 3' untranslated region (3'UTR) of HPGD mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin dehydrogenase 1.
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Zinc finger SNAI2 (SNAI2)		Lung cancer		Repression
Uniprot ID	SNAI2_HUMAN
Interaction Name	SNAI2-HPGD interaction				[3]
Studied Cell Lines	NSCLC cell line
Ensembl ID	ENSG00000019549
Description	Zinc finger SNAI2 (SNAI2) is reported to repress the transcription of HPGD gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin dehydrogenase 1. As a result, the interaction between SNAI2 and HPGD can repress the drug-metabolizing process of Prostaglandin dehydrogenase 1.
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Significant hypomethylation
Interaction Name	DNMT-HPGD interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 9.20E-07; delta-beta: -4.15E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the HPGD gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Prostaglandin dehydrogenase 1. As a result, the interaction between DNMT and HPGD can significantly affect the drug-metabolizing process of Prostaglandin dehydrogenase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma. BMC Cancer. 2016 Aug 25;16(1):685.
2	miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth. Mol Cancer Ther. 2014 Jun;12(6):890-900.
3	Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer. Cancer Res. 2007 Jun 15;67(12):5587-93.

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