Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0567)
DME Name	Quinone reductase 2 (NQO2), Homo sapiens	DME Info
UniProt ID	NQO2_HUMAN
EC Number	EC: 1.10.5.1 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Diphenol donor oxidoreductase Quinone oxidoreductase EC: 1.10.5.1
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lung cancer		Moderate hypomethylation
Interaction Name	DNMT-NQO2 interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypomethylation p-value: 9.05E-15; delta-beta: -2.19E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NQO2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Quinone reductase 2. As a result, the interaction between DNMT and NQO2 can moderatly affect the drug-metabolizing process of Quinone reductase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C90 Renal cell carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Renal cell carcinoma		Significant hypermethylation
Interaction Name	DNMT-NQO2 interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Significant hypermethylation p-value: 2.95E-05; delta-beta: 3.39E-02
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NQO2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Quinone reductase 2. As a result, the interaction between DNMT and NQO2 can significantly affect the drug-metabolizing process of Quinone reductase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section

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