Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0572)
DME Name	Lipocalin-type prostaglandin-D synthase (PTGDS), Homo sapiens	DME Info
UniProt ID	PTGDS_HUMAN
EC Number	EC: 5.3.99.2 (Click to Show/Hide the Complete EC Tree) Isomerase Intramolecular oxidoreductase Intramolecular oxidoreductase EC: 5.3.99.2
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Nuclear factor kappa-B p105 (NFKB1)		Health		Activation
Uniprot ID	NFKB1_HUMAN
Interaction Name	NFKB1-PTGDS interaction				[1]
Studied Cell Lines	Human chondrocytes
Ensembl ID	ENSG00000109320
Description	Nuclear factor kappa-B p105 (NFKB1) is reported to activate the transcription of PTGDS gene, which leads to an increased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between NFKB1 and PTGDS can activate the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
Upstream stimulatory 1 (USF1)		Health		Activation
Uniprot ID	USF1_HUMAN
Interaction Name	USF1-PTGDS interaction				[2]
Studied Cell Lines	Human brain-derived TE671 cell line
Ensembl ID	ENSG00000158773
Description	Upstream stimulatory 1 (USF1) is reported to activate the transcription of PTGDS gene, which leads to an increased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between USF1 and PTGDS can activate the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 11 HOSPPI
Transcription-factor regulation
TF factor AP-2-beta (TFAP2B)		Medulloblastoma		Activation
Uniprot ID	AP2B_HUMAN
Interaction Name	TFAP2B-PTGDS interaction				[3]
Studied Cell Lines	TE671 cell line
Ensembl ID	ENSG00000008196
Description	TF factor AP-2-beta (TFAP2B) is reported to activate the transcription of PTGDS gene, which leads to an increased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between TFAP2B and PTGDS can activate the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
TF factor HES-1 (HES1)		Medulloblastoma		Repression
Uniprot ID	HES1_HUMAN
Interaction Name	HES1-PTGDS interaction				[3]
Studied Cell Lines	TE671 cell line
Ensembl ID	ENSG00000114315
Description	TF factor HES-1 (HES1) is reported to repress the transcription of PTGDS gene, which leads to a decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between HES1 and PTGDS can repress the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
Upstream stimulatory 1 (USF1)		Medulloblastoma		Repression
Uniprot ID	USF1_HUMAN
Interaction Name	USF1-PTGDS interaction				[4]
Studied Cell Lines	TE671 cell line
Ensembl ID	ENSG00000158773
Description	Upstream stimulatory 1 (USF1) is reported to repress the transcription of PTGDS gene, which leads to a decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between USF1 and PTGDS can repress the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DNA methylation
DNA methyltransferase (DNMT)		Brain neuroepithelial tumour		Moderate hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 1.26E-07; delta-beta: 2.04E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PTGDS gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can moderatly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Central neurocytoma		Significant hypomethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.08E-07; delta-beta: -4.47E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PTGDS gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can significantly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Melanocytoma		Significant hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 5.74E-05; delta-beta: 4.58E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PTGDS gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can significantly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Significant hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 6.52E-08; delta-beta: 3.22E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PTGDS gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can significantly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Cerebellar liponeurocytoma		Moderate hypomethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.27E-04; delta-beta: -2.60E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PTGDS gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can moderatly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Diffuse midline glioma		Moderate hypomethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 3.42E-16; delta-beta: -2.96E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PTGDS gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can moderatly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Atypical teratoid/rhabdoid tumour		Moderate hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 2.38E-09; delta-beta: 2.77E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PTGDS gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can moderatly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Peripheral neuroectodermal tumour		Significant hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 4.17E-06; delta-beta: 4.14E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PTGDS gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can significantly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B5F Uterine carcinosarcoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Uterine carcinosarcoma		Moderate hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 4.08E-04; delta-beta: 2.38E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PTGDS gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can moderatly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lung cancer		Significant hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Significant hypermethylation p-value: 6.47E-03; delta-beta: 7.04E-02
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PTGDS gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can significantly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Esthesioneuroblastoma		Significant hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 6.21E-05; delta-beta: 3.33E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PTGDS gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can significantly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Posterior fossa ependymoma		Significant hypomethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.07E-30; delta-beta: -3.19E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PTGDS gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can significantly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F9A Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Craniopharyngioma		Significant hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 6.77E-08; delta-beta: 3.71E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the PTGDS gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can significantly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5A61 Pituitary gland hypofunction		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Chordoma		Moderate hypermethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 7.35E-05; delta-beta: 2.33E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PTGDS gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can moderatly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 5B81 Obesity		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Obesity		Significant hypomethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.57E-13; delta-beta: -3.29E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PTGDS gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can significantly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 12 Respiratory system diseases
ICD-11: CB03 Idiopathic pulmonary fibrosis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Idiopathic pulmonary fibrosis		Moderate hypomethylation
Interaction Name	DNMT-PTGDS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 4.34E-02; delta-beta: -2.39E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PTGDS gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Lipocalin-type prostaglandin-D synthase. As a result, the interaction between DNMT and PTGDS can moderatly affect the drug-metabolizing process of Lipocalin-type prostaglandin-D synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage. Arthritis Res Ther. 2008;10(6):R146.
2	Cooperative activation of lipocalin-type prostaglandin D synthase gene expression by activator protein-2beta in proximal promoter and upstream stimulatory factor 1 within intron 4 in human brain-derived TE671. Cells Gene. 2007 Aug 1;397(1-2):143-52.
3	Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells. J Biol Chem. 2005 May 6;280(18):18452-61.
4	Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. Gene. 2008 Dec 15;426(1-2):72-80.

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