Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0573) | |||||
|---|---|---|---|---|---|
| DME Name | Cathepsin K (CTSK), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.4.22.38 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 8 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.68E-54; delta-beta: -5.10E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CTSK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can significantly affect the drug-metabolizing process of Cathepsin K. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.00E-12; delta-beta: -2.44E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CTSK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can moderatly affect the drug-metabolizing process of Cathepsin K. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Mixed neuronal-glial tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.28E-14; delta-beta: -2.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CTSK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can moderatly affect the drug-metabolizing process of Cathepsin K. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.26E-08; delta-beta: -3.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CTSK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can significantly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.44E-09; delta-beta: -2.82E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CTSK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can moderatly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.04E-20; delta-beta: -2.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CTSK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can moderatly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 9.05E-08; delta-beta: 2.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CTSK gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can moderatly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.59E-10; delta-beta: -3.66E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CTSK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can significantly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.81E-38; delta-beta: -2.76E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CTSK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can moderatly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Significant hypermethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.46E-03; delta-beta: 3.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CTSK gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can significantly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 1.74E-22; delta-beta: 7.40E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CTSK gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can significantly affect the drug-metabolizing process of Cathepsin K. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C73 Ovarian cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Ovarian cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.57E-03; delta-beta: 3.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CTSK gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can significantly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.11E-04; delta-beta: 5.79E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CTSK gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can significantly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C90 Renal cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Transcription-factor regulation | |||||
| Microphthalmia-associated TF (MITF) | Renal cell carcinoma | Activation | |||
| Uniprot ID | |||||
| Interaction Name | MITF-CTSK interaction | [1] | |||
| Studied Cell Lines | Renal cell carcinoma cell line | ||||
| Ensembl ID | |||||
| Description | Microphthalmia-associated TF (MITF) is reported to activate the transcription of CTSK gene, which leads to an increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between MITF and CTSK can activate the drug-metabolizing process of Cathepsin K. | ||||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Moderate hypermethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.29E-04; delta-beta: 2.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the CTSK gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can moderatly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-CTSK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.10E-17; delta-beta: -4.06E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CTSK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cathepsin K. As a result, the interaction between DNMT and CTSK can significantly affect the drug-metabolizing process of Cathepsin K. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| References | |||||
|---|---|---|---|---|---|
| 1 | Differential expression of cathepsin K in neoplasms harboring TFE3 gene fusions. Mod Pathol. 2011 Oct;24(10):1313-9. | ||||
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