Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0575) | |||||
|---|---|---|---|---|---|
| DME Name | Ras proteins prenyltransferase alpha (FNTA), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.5.1.58 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 8 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.58E-21; delta-beta: 2.46E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the FNTA gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.99E-15; delta-beta: -4.23E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FNTA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can significantly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.01E-10; delta-beta: -4.05E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FNTA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can significantly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Vestibular melanotic schwannoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.42E-03; delta-beta: -2.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.92E-14; delta-beta: 4.32E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FNTA gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can significantly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Significant hypermethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 7.76E-11; delta-beta: 5.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FNTA gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can significantly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.99E-03; delta-beta: -2.86E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.95E-08; delta-beta: -2.82E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.95E-20; delta-beta: -2.89E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.65E-07; delta-beta: -2.38E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B90 Colorectal cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Colorectal cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.44E-37; delta-beta: -2.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.00E-02; delta-beta: -2.93E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C73 Ovarian cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Ovarian cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.83E-03; delta-beta: -2.31E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Significant hypermethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.24E-02; delta-beta: 3.54E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the FNTA gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can significantly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F7C Connective tissue cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Hemangioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.05E-08; delta-beta: -2.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-FNTA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.59E-11; delta-beta: -2.74E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FNTA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Ras proteins prenyltransferase alpha. As a result, the interaction between DNMT and FNTA can moderatly affect the drug-metabolizing process of Ras proteins prenyltransferase alpha. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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