Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0576) | |||||
|---|---|---|---|---|---|
| DME Name | N-acetyl-D-glucosamine 2-epimerase (AGE), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 5.1.3.8 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 8 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.43E-02; delta-beta: -2.05E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AGE gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.14E-09; delta-beta: -2.64E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AGE gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Central neurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.98E-02; delta-beta: -2.45E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AGE gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.25E-04; delta-beta: -2.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AGE gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.50E-08; delta-beta: -2.54E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AGE gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.64E-03; delta-beta: -2.49E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AGE gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 7.09E-13; delta-beta: 2.78E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the AGE gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pleomorphic xanthoastrocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.76E-03; delta-beta: -2.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AGE gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.26E-02; delta-beta: -2.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AGE gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 08 Nervous system diseases | |||||
| ICD-11: 8E49 Postviral fatigue syndrome | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Postviral fatigue syndrome | Moderate hypermethylation | |||
| Interaction Name | DNMT-AGE interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.95E-05; delta-beta: 2.86E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the AGE gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme N-acetyl-D-glucosamine 2-epimerase. As a result, the interaction between DNMT and AGE can moderatly affect the drug-metabolizing process of N-acetyl-D-glucosamine 2-epimerase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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