Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0579) | |||||
|---|---|---|---|---|---|
| DME Name | Glutamate carboxypeptidase II (FOLH1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.4.17.21 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-FOLH1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.09E-07; delta-beta: -2.32E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FOLH1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutamate carboxypeptidase II. As a result, the interaction between DNMT and FOLH1 can moderatly affect the drug-metabolizing process of Glutamate carboxypeptidase II. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Moderate hypomethylation | |||
| Interaction Name | DNMT-FOLH1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.32E-02; delta-beta: -2.38E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FOLH1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Glutamate carboxypeptidase II. As a result, the interaction between DNMT and FOLH1 can moderatly affect the drug-metabolizing process of Glutamate carboxypeptidase II. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Significant hypomethylation | |||
| Interaction Name | DNMT-FOLH1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.38E-09; delta-beta: -3.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FOLH1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Glutamate carboxypeptidase II. As a result, the interaction between DNMT and FOLH1 can significantly affect the drug-metabolizing process of Glutamate carboxypeptidase II. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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