Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0583) | |||||
|---|---|---|---|---|---|
| DME Name | Retinol dehydrogenase 5 (RDH5), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.1.315 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 8 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.14E-06; delta-beta: -3.00E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the RDH5 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pilocytic astrocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 8.15E-12; delta-beta: -3.57E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the RDH5 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.83E-07; delta-beta: -2.38E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the RDH5 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can moderatly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Central neurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.07E-10; delta-beta: -6.56E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the RDH5 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebral hemispheric glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.79E-03; delta-beta: -2.98E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the RDH5 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can moderatly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.44E-07; delta-beta: 2.25E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the RDH5 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can moderatly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.16E-06; delta-beta: -6.16E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the RDH5 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pleomorphic xanthoastrocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.48E-07; delta-beta: -5.03E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the RDH5 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Significant hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.83E-47; delta-beta: -3.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the RDH5 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 4.65E-07; delta-beta: 2.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the RDH5 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can moderatly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Significant hypermethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 6.00E-05; delta-beta: 3.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the RDH5 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 2.35E-03; delta-beta: 4.34E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the RDH5 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 2.27E-09; delta-beta: -2.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the RDH5 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can moderatly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.79E-08; delta-beta: 4.83E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the RDH5 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.24E-13; delta-beta: -3.97E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the RDH5 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.23E-69; delta-beta: -5.94E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the RDH5 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypermethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.15E-04; delta-beta: 5.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the RDH5 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.75E-08; delta-beta: -2.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the RDH5 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can moderatly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Significant hypermethylation | |||
| Interaction Name | DNMT-RDH5 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 2.88E-02; delta-beta: 4.37E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the RDH5 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Retinol dehydrogenase 5. As a result, the interaction between DNMT and RDH5 can significantly affect the drug-metabolizing process of Retinol dehydrogenase 5. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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