General Information of Drug-Metabolizing Enzyme (DME ID: DME0584)
DME Name Carboxymethylenebutenolidase (CMBL), Homo sapiens DME Info
UniProt ID
CMBL_HUMAN
EC Number    EC: 3.1.1.45     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.45
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Multilayered rosettes embryonal tumour Significant hypermethylation
Interaction Name DNMT-CMBL interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypermethylation
p-value: 5.78E-12; delta-beta: 3.86E-01
Description DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CMBL gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Carboxymethylenebutenolidase. As a result, the interaction between DNMT and CMBL can significantly affect the drug-metabolizing process of Carboxymethylenebutenolidase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

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