Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0584)
DME Name	Carboxymethylenebutenolidase (CMBL), Homo sapiens	DME Info
UniProt ID	CMBL_HUMAN
EC Number	EC: 3.1.1.45 (Click to Show/Hide the Complete EC Tree) Hydrolases Ester bond hydrolase Carboxylic ester hydrolase EC: 3.1.1.45
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Significant hypermethylation
Interaction Name	DNMT-CMBL interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 5.78E-12; delta-beta: 3.86E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CMBL gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Carboxymethylenebutenolidase. As a result, the interaction between DNMT and CMBL can significantly affect the drug-metabolizing process of Carboxymethylenebutenolidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.