| General Information of Drug-Metabolizing Enzyme (DME ID: DME0586) |
| DME Name |
Short-chain dehydrogenase/reductase retSDR8 (DHRS9), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 1.1.1.53 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.53
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C90 Renal cell carcinoma |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Renal cell carcinoma |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-DHRS9 interaction |
[1] |
| Studied Cell Lines |
Human renal cell carcinoma (RCC) lines |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the DHRS9 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Short-chain dehydrogenase/reductase retSDR8. As a result, the interaction between HDACs and DHRS9 can inhibit the drug-metabolizing process of Short-chain dehydrogenase/reductase retSDR8. |
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| References |
| 1 |
Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
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